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Abstract #2951

High Resolution Dynamic 31P-MRSI of Ischemia-Reperfusion in Rat Hindlimb at 9.4T Using SPICE

Yuchi Liu1,2, Bryan Alexander Clifford3,4, Chao Ma3,5,6, Fan Lam3, Zhi-Pei Liang3,4, and Xin Yu1,2,7,8

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Gordon Center for Medical Imaging, NMMI, Department of Radiology, Massachusetts General Hospital, MA, United States, 6Department of Radiology, Harvard Medical School, MA, United States, 7Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 8Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Dynamic 31P-MRSI serves as a non-invasive tool to assess mitochondrial oxidative capacity in skeletal muscle during ischemia-reperfusion or exercise-recovery. However, 31P-MRSI with high spatial resolution requires long acquisition times which render dynamic measurements impractical. In this study, we adapted a recently proposed low-rank tensor-based method for high-resolution dynamic 31P-MRSI in preclinical studies. We present results from an in vivo ischemia-reperfusion experiment on a rat hindlimb with 15 s nominal temporal resolution and 0.75×0.75×1.6 mm3 nominal spatial resolution, demonstrating the potential of the method for assessing mitochondrial function in different muscle types in small animal models.

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