Abstract #2849

Quantification of cerebrospinal fluid flow through the cerebral aqueduct using 7T MRI

JM Spijkerman¹, JCW Siero^1,2, LJ Geurts¹, MJ Donahue³, J Hendrikse¹, PR Luijten¹, and JJM Zwanenburg¹

¹Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Spinoza Center for Neuroimaging, Amsterdam, Netherlands, ³Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, United States

In this work the feasibility of recording high spatial resolution quantitative flow (Qflow) measurements in the cerebral aqueduct at 7T was investigated. Five volunteers were scanned, two encoding velocities (v_enc) were used: 5 and 13 cm/s. Repeated measurements were performed (v_enc=5cm/s: n=4; v_enc=13 cm/s: n=5). Mean net CSF flow through the aqueduct (directed towards the spine) was (mean±std) 332±128 ml/day for v_enc=5cm/s and 441±149 ml/day for v_enc=13cm/s, which is in accordance with values found in literature. Reasonable reproducibility of the measurements was found.

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