Abstract #2782

Assessment of Local Pulse-Wave-Velocity Distribution in Mice using k-t BLAST MRI with Semi-Automatic Area Segmentation

Volker Herold¹, Patrick Winter¹, Stefan Herz², Fabian Gutjahr¹, Kristina Andelovic³, Wolfgang Rudolf Bauer³, and Peter Michael Jakob¹

¹Department of Physics, University of Würzburg, Würzburg, Germany, ²Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, ³Department of Internal Medicine I, Division of Cardiology, University Hospital Würzburg, Würzburg, Germany

Arterial stiffness (AS) assessed by pulse wave velocity (PWV) has been shown to represent a valuable biomarker of cardiovascular disease risk. Local elastic properties of the murine aortic vessels such as the pulse-wave-velocity (PWV) can be examined using PC-MRI [1]. In the present study we provide an accelerated method based on a k-t BLAST undersampling scheme combined with a new semi-automatic segmentation algorithm to quantify the distribution of the local PWV along the aortic vessel.

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