Abstract #2780

Quantitative characterization of calcified and lipid-laden blood clot in vitro at 3T

Spencer D Christiansen^1,2, Junmin Liu¹, Trevor Wade¹, Joy Dunmore-Buyze¹, Michael B Boffa³, Luciano Sposato⁴, and Maria Drangova^1,2

¹Imaging Research Laboratories, Robarts Research Institute, Western University, London, ON, Canada, ²Dept. of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ³Dept. of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ⁴Dept. of Clinical Neurological Sciences, Western University, London, ON, Canada

Thrombus composition in embolic occlusion, particularly the presence of thrombolysis-resistant components such as calcium and fat, can significantly influence treatment efficacy, yet current MR methods for inferring composition are qualitative and sensitive only to red blood cells. We examined the ability of novel post-processing algorithms applied to a tailored GRE acquisition to discriminate and quantify important components within in vitro blood clots of varied hematocrit over a nine-day ageing period. Calcium and lard were readily discernable throughout the experiment, while clots were differentiable from one another between two to six days, demonstrating this protocol's potential for thrombus characterization in vivo.

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