Cerebrospinal fluid (CSF) β-amyloid and phosphorylated-tau are consistently used as biomarkers related to the pathophysiology and clinical severity of individuals in the earliest phases of Alzheimer’s disease (AD). This study shows that T1-weighted and FLAIR signal intensity in the hippocampal subfields, normalized using the fimbria, are associated with ApoE4 status and CSF biomarkers. The FLAIR results suggest that presence of inflammation in the subiculum of ApoE4 carriers and in the CA1 and molecular layers of the hippocampus in subjects with low CSF β-amyloid burden as tau pathology increases.
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