Based on gradient echo (GRE) magnetic resonance phase data, quantitative susceptibility mapping (QSM) is a novel technique which allows the non-invasive assessment of magnetic tissue susceptibility distribution in mild alzheimer’s disease (AD). In this study ,we investigated the correlation between mini-mental state examination (MMSE) and bulk tissue magnetic susceptibility in subcortical nuclei of 14 mild AD subjects and 14 cognitively healthy controls scanned at 3T . A strong linear correlation between them was found in caudate nucleus and dentate nucleus. Hence, QSM can be used for early AD diagnosis and intervention.
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