The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) or their effects on cognition has rarely been investigated. The purposes of the present study were to investigate brain iron deposition in deep gray matter nuclei in svMCI patients using quantitative susceptibility mapping (QSM) and its correlation with the severity of cognitive impairment. Susceptibility values were found to be elevated within bilateral hippocampus and right putamen in svMCI group compared with controls, which were related to cognitive measurements. Our result suggests that brain iron deposition which relation to cognition indicates the clinical relevance of the biomarker.
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