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Abstract #2341

Neuromelanin-weighted MRI in revealing human development and age-related changes in locus coeruleus and substantial nigra

Yue Xing1,2, Abdul Halim Sapuan1, Robert Dineen1,3, Andrew Cooper4, and Dorothee Auer4

11Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, United Kingdom, 4Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Queen’s Medical Centre;, University of Nottingham, Nottingham, United Kingdom

Rapid neuromelanin-weighted MR imaging sequence was performed to noninvasively inspect the physiological changes of substantial nigra and Locus ceruleus across a wide range of age in healthy subjects using neuromelanin-sensitive MRI for the first time.

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