This study examines the sensitivity of DTI metrics to proximal sciatic nerve pathology in a cohort of patients with Charcot-Marie-Tooth (CMT) diseases and matched controls, with the longer-term goal of developing objective biomarker of disease progression and treatment response. Prior studies have shown that DTI metrics can relate to disability in other neuropathies. Here we demonstrate that robust DTI can be performed in the proximal sciatic nerve of patients with CMT, and the resulting metrics are sensitive to myelin and/or axonal pathologies. Future studies will test if DTI measures predict disability in patients with CMT.
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