Multimodal diffusion MRI and quantitative MT techniques were used to examine the nature of abnormalities in the corticospinal tracts (CSTs) of amyotrophic lateral sclerosis (ALS) patients. Our data show reductions in axonal volume fraction (AVF) located superiorly to reductions in myelin volume fraction (MVF). We also find extensive decreases in fiber volume fraction (FVF) throughout the entire CST, supporting the hypothesis of axonal loss as the primary pathological mechanism in ALS.
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