Abstract #1939

Hemodynamic response to respiratory challenge evaluated by dynamic R2’ imaging: application for acute renal ischemia caused by microsphere-induced renal artery embolism

Chengyan Wang¹, Bihui Zhang², Haochen Wang², Hanjing Kong¹, Fei Gao³, Li Jiang⁴, He Wang⁵, Xiaodong Zhang⁶, Min Yang², Jue Zhang^1,3, Xiaoying Wang^1,6, and Jing Fang^1,3

¹Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, People's Republic of China, ²interventional radiology and vascular surgery, Peking University First Hospital, Beijing, People's Republic of China, ³College of Engineering, Peking University, Beijing, People's Republic of China, ⁴Philips Healthcare, Suzhou, People's Republic of China, ⁵Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, People's Republic of China, ⁶Department of Radiology, Peking University First Hospital, Beijing, People's Republic of China

The clinical use of iodinated or gadolinium contrast agents for renal hemodynamic imaging is limited in the presence of renal dysfunction due to its increased risks of exacerbating renal damage. Therefore, we performed a modified HRI technique with a specific-designed magnetic-susceptible sequence that could separate R2’ from the BOLD signals in a unilateral microemboli-induced AKI model. The results show that R2’ in normal or less affected regions reduced after carbogen challenge, while the R2’ in the most affected lesions increased significantly. The dR2’ map could indicate the most affected areas accurately confirmed with the final anatomic T2w image.

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