Multi-echo (ME) DSC-MRI enables the simultaneous assessment of contrast-agent induced T1 and T2* changes, but its sensitivity to and the quantification of these T1 changes could be confounded by long TR and TE. Using simulations, we demonstrate that conventional 2D ME scans underestimate contrast agent concentration and DCE-MRI kinetic parameters. To solve this problem, we propose a 3D ME spiral acquisition that enables lower TRs and minimal TEs for improved T1 quantification and a range of echo times to main T2* sensitivity.
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