Abstract #1898

Can We Trust TRUST Venous Oximetry in Sickle Cell Disease?

Adam Michael Bush¹, Thomas Coates², Herbert Meiselman³, and John Wood⁴

¹Biomedical Engineering/ Cardiology, University of Southern California/ Children's Hospital Los Angeles, Los Angeles, CA, United States, ²Hematology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ³Physiology and Biophysics, University of Southern California, Los Angeles, CA, United States, ⁴Cardiology, University of Southern California/ Children's Hospital Los Angeles, Los Angeles, CA, United States

In this work we derive a de novo T_2b oximetry calibration curve for hemaglobin S containing red blood cells. We then compare predictions made by this calibration and existing T_2b calibrations in 84 subjects in vivo using TRUST MRI. We found that predictions for venous oxygenation saturation and cerebral metabolic rate are widely different depending on the T_2b calibration used for oximetry conversion.

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