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Abstract #1875

White matter abnormalities of brain and cervical spinal cord in Hepatic Myelopathy patients: a diffusion tensor imaging study

Liu-Xian Wang1, Lin Liu2, Kang Liu3, Ning-Bo Fei4, Long-Biao Cui3, Yi-Bin Xi3, Ting-Ting Liu3, Wei Qin2, and Hong Yin3

1Department of Radiology, Xijing Hospital, The Fourth Military Medical University, shaanxi, xi'an, People's Republic of China, 2School of Life Sciences and Technology, Xidian University, People's Republic of China, 3the fourth military medical university, People's Republic of China, 4School of Life Sciences and Technology, Xidian University, xi'an, People's Republic of China

The prominent syndrome of HM such as spastic paraparesis is usually considered resulting from abnormal function of thoracic segments, nevertheless, the involvement of intracranial fibers and cervical spinal cord is not clear. In this study, we found a widespread and robust white matter tract abnormality in brain of HM and non-HM patients, without significant difference with cervical spinal cord. Our finding may help shedding light on the underlying pathological mechanism of HM.

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Abstract