Abstract #1753

In-vivo whole-brain Neurite Orientation Dispersion and Density Imaging at sub-millimeter scale using gSlider-SMS

Elda Fischi-Gomez^1,2, Susie Y. Huang^1,2, Hui Zhang³, and Kawin Setsompop^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital. Department of Radiology, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Department of Computer Science & Centre for Medical Image Computing, University College London, United Kingdom

We demonstrate the feasibility of applying microstructural models of diffusion to sub-millimeter isotropic resolution whole brain images in-vivo. The NODDI model was successfully fitted to a 700µm DWI dataset acquired using the generalized SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (gSlider-SMS) acquisition¹. We demonstrate the ability to map finer-scale structures using this high-resolution data when compared to traditional multi-shell 2 mm isotropic acquisition.

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