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Abstract #1593

Quantitative Mapping of the Ischemic Femoral Head in a Piglet Model of Legg-Calve-Perthes Disease

Casey P. Johnson1, Luning Wang1, Ferenc Toth2, Cathy S. Carlson2, Harry K. W. Kim3,4, and Jutta M. Ellermann5

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Veterinary Population Medicine, University of Minnesota, St. Paul, MN, United States, 3Texas Scottish Rite Hospital, Dallas, TX, United States, 4Orthopaedic Surgery, UT Southwestern, Dallas, TX, United States, 5Radiology, University of Minnesota, Minneapolis, MN, United States

This study investigated the sensitivities of T1, T2, continuous-wave T1ρ, adiabatic T1ρ, and RAFF relaxation times to ischemia-induced necrosis and subsequent repair of the developing femoral head in a piglet model of Legg-Calve-Perthes disease (LCPD), a disabling childhood hip disorder. Quantitative maps of ischemic and control femoral heads acquired ex vivo at 9.4T MRI were compared numerically and validated with histology. Our findings reveal that the relaxation times provide complementary information on the status of the pathological hip, which can potentially address a clinical need for diagnostic imaging tools to assess the early stages of LCPD.

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