Abstract #1573

Targeted modulation of retinoid signaling using polymeric nanoparticles in a mouse model of Amyotrophic Lateral Sclerosis

David Medina¹, Eugene Chung¹, Ricki Ceton¹, Robert Bowser¹, Rachael Sirianni¹, and Gregory Turner²

¹Neurobiology, Barrow Neurological Institute, Phoenix, AZ, United States, ²Research Imaging, Barrow Neurological Institute, Phoenix, AZ, United States

Retinoid signaling activity in the CNS, mediated by RARβ, directly influences ALS pathology development and progression in vivo and CNS targeted delivery of RARβ agonists can reduce ALS pathology in vivo when delivered systemically via polymeric nanoparticles. In this study the therapeutic affect of adapalene, a RARβ agonist, loaded nanoparticles were examined by measuring quadriceps volume in a SOD1^G93A mouse model of ALS.

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