Abstract #1572

Correlating MRI and Histological Parameters in GRMD Muscles: A Comparison Between 3T and 4.7T Acquisitions

Aydin Eresen¹, Stephen McConnell¹, Sharla Birch², Wade Friedeck³, Jay Griffin⁴, Joe Kornegay⁵, and Jim Ji¹

¹Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, United States, ²Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, United States, ³Small Animal Imaging and Radiology, Texas A&M University, College Station, TX, United States, ⁴Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, United States, ⁵Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States

The relationship between localized histological truth and various MRI quantitative measures were investigated using canine models. In this study, GRMD pectineus muscle samples were imaged on a 3T clinical scanner and a 4.7T small-bore scanner. Trichrome stained histology slice was registered to the 3D MRI volume. Localized quantitative MRI parameters are correlated with histology analysis (muscle, fibrosis and interstitial tissue percentage). Parameters derived from the 4.7T MRI data show consistent correlations, while those from 3T MRI data do not show consistent correlation.

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