Abstract #1334

Zero-echo-time PET/MRI attenuation correction shows good correlation between 15O-water PET and simultaneously acquired ASL in standard regional flow territories

Markus Fahlström¹, Karolina Lindskog², Lieuwe Appel¹, Mathias Engström³, Johan Wikström¹, Gunnar Antoni⁴, Eva Kumlien⁵, Elna-Marie Larsson¹, and Mark Lubberink¹

¹Surgical Sciences, Uppsala University, Uppsala, Sweden, ²Biomedical Technology, Medical Physics and IT, Uppsala University Hospital, Uppsala University Hospital, Uppsala, Sweden, ³Applied Science Laboratory, GE Healthcare, Uppsala, Sweden, ⁴Medicinal Chemistry, Uppsala University, Uppsala, Sweden, ⁵Neuroscience, Uppsala University, Uppsala, Sweden

Zero-Echo-Time (ZTE) MRI for attenuation correction (AC) in hybrid PET/MRI-systems is a promising method. This study aims to examine reproducibility between 15O-water PET and simultaneously acquired Arterial Spin Labelling (ASL) using ZTE-MRI AC and the reproducibility between to subsequent ASL measurements. Measurements were performed on six subjects on an integrated 3.0 T PET/MRI-system. Regional cerebral blood flow (CBF) values from standard flow territories were compared. ASL showed good correlation with 15O-water PET, presenting another advantage of ZTE-MRI AC. A significant decrease between ASL measurements was detected, which may be important to consider when designing PET/MRI-studies.

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