Multiparametric MRI is the standard to evaluate suspected prostate cancer. T2-weighted and DWI are essential, while DCE is less crucial. We here demonstrate that simultaneous quantification of ADC, T2-relaxation and perfusion fraction f, which was calculated from non-IVIM low b-value data, is feasible in combination with 11C-acetate PET/MR imaging. ADC and T2-values differed significantly between healthy tissue and cancer, while f was more inconsistent. An important benefit of simultaneous acquisition is the lack of image mismatch between T2-maps and DWI. This enables more objective tumor grading, decreased inter-rater variability and using mathematical/statistical approaches or computer-aided detection to estimate cancer probability.
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