Abstract #1254

Brain-Structure-Specific Metabolite Quantification of MEGA-LASER 3D MRSI data

Ruoyun Ma^1,2, Wolfgang Bogner³, Ovidiu C. Andronesi⁴, and Ulrike Dydak^1,2

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Department of Radiology and Imaging Sciences, Indidana University School of Medicine, Indianapolis, IN, United States, ³Department of Biomedical Imaging and Image-guided Therapy, High Field MR Center, Medical University of Vienna, Vienna, Austria, ⁴Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

To overcome box-shaped ROIs and enable brain-structure-specific comparison of metabolite levels across patient groups, a fully-automated brain-structure-specific metabolite quantification approach was developed and applied to the analysis of MEGA-LASER 3D MRSI data. Structure-specific GABA, Glx, NAA and tCho levels and their hemispheric variation in healthy volunteers was studied. The four metabolite levels varied significantly across different brain regions, but did not differ between left and right hemispheres. Correlations between the left and right hemisphere metabolite levels were observed only for some structures.

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