Abstract #1253

Spiral-accelerated short-TE MRSI with B1-insensitive 1D-semiLASER localization and real-time motion correction at 7T

Philipp Moser¹, Bernhard Strasser¹, Lukas Hingerl¹, Michal Povazan^1,2, Gilbert Hangel¹, Ovidiu C. Andronesi³, Borjan Gagoski⁴, Aaron T. Hess⁵, Dylan M. Tisdall⁶, Andre van der Kouwe³, Siegfried Trattnig^1,2, and Wolfgang Bogner¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria, ³Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ⁴Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, ⁵Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁶Perelman School of Medicine, Department of Radiology, University of Pennsylvania, Pennsylvania, PA, United States

In vivo MRSI at 7T offers advantages compared to lower field strengths, in particular higher SNR and improved spectral resolution. However, spectral quality is often limited by strong B1+ inhomogeneities, motion-related artifacts and scanner instability related B0 field drifts. To overcome these limitations, we have developed a 1D-semiLASER 2D-spiral-encoded MRSI sequence with real-time motion monitoring/correction using 3D EPI-based navigators (vNavs). Besides sequence stability we show that accurate B1-insensitive excitation can be achieved throughout the slice until the border of the brain. Using 7T-optimized motion correction, high spectral and metabolic map qualities are feasible even in the presence of motion.

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