Abstract #1154

GABA promotes beta-Amyloid related changes in dynamic network expression of elderly subjects at risk for Alzheimer's disease

Frances-Catherine Quevenco¹, Simon J. Schreiner^2,3, Maria Giulia Preti⁴, Jiri van Bergen¹, Thomas Kirchner⁵, Michael Wyss⁵, Stephanie C. Steininger^1,3, Anton Gietl¹, Sandra Leh^1,3, Alfred Buck⁶, Klaas P. Pruessman⁵, Christoph Hock^2,3, Roger M. Nitsch², Anke Henning^5,7, Dimitri Van de Ville⁴, and Paul Gerson Unschuld^2,8

¹Institute of Regenerative Medicine, University of Zurich, Zurich, Switzerland, ²Institute for Regenerative Medicine, University of Zurich, Switzerland, ³Hospital for Psychogeriatric Medicine, University of Zurich, Switzerland, ⁴Institute of Bioengineering, École polytechnique fédérale de Lausanne, Switzerland, ⁵Institute for Biomedical Engineering, ETH Zurich, Switzerland, ⁶Division of Nuclear Medicine, University of Zurich, Switzerland, ⁷Max Planck Institute for Biological Cybernetics, Tubingen, Germany, ⁸Hospital for Psychogeriatric Medicine, University of Zurich, Zurich, Switzerland

This study observes dynamic functional connectivity changes in an elderly AD-risk population mediated by both regional Aß-deposits and GABA levels, using PiB-PET and MRSI. The sample is grouped into subjects with high regional Aß and high GABA, and changes in dynamic network expression are compared between groups. Our preliminary findings show dynamic network changes specific to high Aß-deposits in the neocortex and the frontal and temporal lobe. This indicates region-specific network changes that may in part explain the weak correlation between global Aß and AD progression.

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