Abstract #1106

Cerebral Sodium (23Na) Magnetic Resonance Imaging in Patients with Migraine

Melissa M Ong¹, Alexander Schmidt¹, Simon Konstandin², Justus Benrath³, Mathias Meyer¹, Lothar R Schad⁴, Stefan O Schoenberg¹, and Stefan Haneder^1,5

¹Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany, ²University of Bremen, MR-Imaging and Spectroscopy, Faculty 01 (Physics/Electrical Engineering), Bremen, Germany, ³Clinic for Anaesthesiology and Operative Intensive Care, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany, ⁴Computer Assisted Clinical Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany, ⁵Institute of Diagnostic and Interventional Radiology, University Hospital Cologne, Cologne, Germany

To evaluate sodium concentrations in subgroups of patients with clinically manifest migraine, 12 patients underwent a cerebral ²³Na-magnetic resonance imaging examination using a dual-tuned (²³Na/¹H), dedicated head-coil. ²³Na-sequences were reconstructed according to a T1 MP-RAGE, allowing direct cross-referencing of predetermined regions-of-interest (ROI). Significant differences in sodium concentrations could be observed for the white matter and anterior cerebrospinal fluid in patients with and without accompanying aura (p<0.05). These data suggest, that cerebral sodium concentrations may have the potential to differentiate between different subgroups of migraine.

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