Abstract #1105

Qualitative and quantitative analysis of amide proton transfer-weighted MR images at 3 Tesla of adult gliomas

Xianlong Wang¹, Hao Yu², Shanshan Jiang², Yu Wang³, Yanyu Wang², Ge Zhang⁴, Chunxiu Jiang², Guodong Song⁵, Yi Zhang⁶, Hye-Young Heo⁶, Jinyuan Zhou⁶, and Zhibo Wen²

¹Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, People's Republic of China, ²Radiology, Zhujiang Hospital of Southern Medical University, ³Pathology, Zhujiang Hospital of Southern Medical University, ⁴Radiology, Hainan General Hospital, ⁵Radiology, Beijing Hospital, ⁶Radiology, Johns Hopkins University

We evaluated the reliability and clinical value of amide proton transfer-weighted (APTW) MR imaging at 3 Tesla in adult gliomas. Fifty-seven patients with primary gliomas were recruited and scanned. Two radiologists evaluated the location and size of the APTW hyperintensity and enhancing areas, and measured the tumor and contralateral normal-appearing white matter (CNAWM) APTW values. The correlation between relative APTW (rAPTW) values and pathologic grades was calculated. Results showed APTW analysis had good reliability. APTW images almost showed the same compared with T1-weighted contrast-enhancing (T1W+C) images. The tumor rAPTW values had a strong positive correlation with pathologic grades.

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