Abstract #1079

Reduced Functional Network Segregation is Associated with Reduced Structural Network Integration and Cost Pre-Operatively in Neonates with Complex Congenital Heart Disease (CHD)

Vincent Schmithorst¹, Vince Lee¹, Jodie K. Votava-Smith², Richard Kim³, Rafael Ceschin⁴, Shahida Sulaiman¹, Hollie Lai⁵, Jennifer Johnson⁶, Joan Sanchez De Toledo⁷, Stefan Bluml⁵, Lisa Paquette⁸, and Ashok Panigrahy¹

¹Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, ²Division of Cardiology, Children's Hospital Los Angeles, ³Division of Pediatric Cardiothoracic Surgery, Children's Hospital Los Angeles, ⁴Department of Biomedical Informatics, University of Pittsburgh, ⁵Radiology, Children's Hospital Los Angeles, ⁶Division of Pediatric Cardiology, University of Pittsburgh School of Medicine, ⁷Department of Critical Care, University of Pittsburgh School of Medicine, ⁸Division of Neonatology, Children's Hospital Los Angeles

Neonates with complex congenital heart disease (CHD) pre-operatively show alterations in both structural network topology (as assessed via DTI) and functional network topology (as assessed via rs-fcMRI). Structurally, decreases in global efficiency, transitivity, and nodal efficiency are driven by decreased network cost and reflect alterations in white matter microstructure such as reduced fiber density. Functionally, CHD neonates display decreased network segregation in the later-developing frontal and temporal lobes, independent of cost, which likely reflect alterations at a more hierarchical level of architecture. These results may stem from different etiologies of brain dysmaturation (hypoperfusion vs. genetic factors).

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