In current study, we demonstrated the altered effective connectivity between bilateral dorsolateral prefrontal cortex(DLPFC) and other brain regions in obsessive compulsive disorder(OCD) using the Granger causality analysis of resting-state functional MRI. We found that the effective connectivity from the bilateral DLPFC to some brain regions are increased or decreased in OCD ,and DLPFC is the important information flow center. We also observed positive correlations between the abnormal causal effect and clinical symptoms such as obsession. These findings provide insight into OCD-related neural network disorders and may potentially guide clinical diagnosis and treatment of OCD in the future.
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