Abstract #0985

Pipeline for longitudinal assessment of patient-derived mouse xenografts using 3D magnetization transfer-weighted MRI

Kimberly L. Desmond¹, David Bakhshinyan², Maleeha Qazi², Parvez Vora², Chirayu Chokshi², Sheila K. Singh², and Nicholas A. Bock¹

¹Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada, ²McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

A pipeline was developed, driven by 3D magnetization transfer-weighted images acquired without contrast agent, to automatically assess mouse models of patient-derived tumours against an atlas of control NOD-SCID mice, for the purposes of longitudinal, high-throughput screening of mice for response to cancer therapy and recurrence.

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