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Abstract #0984

In vivo assessment of tumour invasion of the visual pathway in optic pathway glioma patients using multi-shell diffusion tensor MRI

Patrick W Hales1, Victoria Smith2, Patricia O'Hare3, Kshitij Mankad4, Felice d'Arco4, Jessica Cooper4, Ramneek Kaur1, Kim Phipps3, Darren Hargrave3, and Christopher A Clark1

1Developmental Imaging & Biophysics Section, University College London, London, United Kingdom, 2Ophthalmology Department, Great Ormond Street Children’s Hospital, London, United Kingdom, 3Haematology and Oncology Department, Great Ormond Street Children’s Hospital, London, United Kingdom, 4Radiology Department, Great Ormond Street Children’s Hospital, London, United Kingdom

Optic pathway glioma (OPG) is a childhood tumour of the visual pathway. Some OPG patients remain stable, whereas others experience rapid visual decline; however, conventional MRI cannot stratify these patients. We used multi-shell DTI to measure tumour invasion of the optic pathway in 23 OPG patients, in conjunction with visual assessment. A strong correlation was found between fractional anisotropy in the optic nerves and optic radiations, and visual acuity (p=0.00092 and p=0.008 respectively). Our study demonstrates that multi-shell diffusion-MRI offers increased sensitivity over conventional MRI in detecting white matter integrity and function in the visual pathway of OPG patients.

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