Abstract #0981

Dynamic Glucose Enhanced MRI - A prospective study in healthy volunteers and glioblastoma patients

Daniel Paech¹, Patrick Schuenke², Christina Koehler¹, Johannes Windschuh², Sibu Mundiyanapurath³, Sebastian Bickelhaupt¹, Philipp Bäumer¹, David Bonekamp¹, Martin Bendszus⁴, Wolfgang Wick³, Peter Bachert², Mark E. Ladd², Heinz-Peter Schlemmer¹, Moritz Zaiss⁵, and Alexander Radbruch¹

¹Radiology, German Cancer Research Center, Heidelberg, Germany, ²Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, ³Neurology, University Hospital Heidelberg, Heidelberg, ⁴Neuroradiology, University Hospital Heidelberg, Heidelberg, ⁵Max-Planck-Institut Tübingen, Tübingen, Germany

Glucose is the main energy source of cancer cells to proliferate and survive. Recently, promising results to assess changes in cellular metabolism using natural unlabeled D-glucose as biodegradable MRI contrast agent, have been reported employing Chemical Exchange Saturation Transfer (CEST) and Chemical Exchange sensitive Spin-Lock (CESL) imaging. In this work, the CESL-based dynamic glucose enhanced (DGE) contrast was investigated in healthy volunteers and a homogenous cohort of newly diagnosed untreated glioblastoma patients at 7 Tesla. DGE MRI allowed for sensitive visualization of physiological glucose uptake in the healthy human brain and pathophysiologically increased glucose enhancement of brain tumors.

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