Abstract #0848

Study Of The Associations Between [18F]-NaF PET Bone Remodeling, MRI Trabecular Bone Structure and Patient Reported Outcomes in subjects with Osteoarthritis

Valentina Pedoia¹, Rohit Curucundhi¹, Dragana Savic², Misung Han¹, Youngho Seo¹, Matthew D. Bucknor¹, Benjamin L. Franc¹, and Sharmila Majumdar¹

¹Radiology and Biomedical Imaging, University Of California, San Francisco, San Francisco, CA, United States, ²Department of Physiology, Anatomy and Genetics, University of Oxford

In Osteoarthritis (OA) degeneration of articular cartilage, are accompanied by changes in subchondral and trabecular bone. In this study we analyzed bone structure, cartilage degeneration and bone remodeling, quantified using simultaneous PET/MRI system in fourteen subjects with radiographic or symptomatic OA. The aim of this study was to evaluate these imaging biomarkers in association with patient reported outcomes for evaluating this technique as a tool for assessing OA. Our results showed associations between Standardized Uptake Values (SUV) and both level of pain measured by KOOS and cartilage degeneration measured using T_1ρ and T₂ relaxation times.

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