Surrogates for bone matrix density, pore volume fraction and mineral density can be studied with solid-state MRI. Here, we developed an in vivo MRI protocol to simultaneously quantify bone mineral 31P and bound and pore water on a 3 Tesla clinical MRI system with a dual-frequency extremity coil and 3D 1H UTE and 31P PETRA-ZTE pulse sequences. Measurements in the mid-tibia of 10 subjects yielded 7.06±1.53mol/L 31P, and 13.99±1.26 and 10.39±0.80mol/L H2O for total and bound water, respectively, in good agreement with prior ex vivo data. The work suggests that both organic and inorganic phases of cortical bone can be quantitatively evaluated in vivo with a single, integrated protocol.
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