Abstract #0722

Validation of DTI-based parcellation of the thalamus in the squirrel monkey

Yurui Gao^1,2, Kurt G Schilling¹, Iwona Stepniewska³, Landman A Bennett⁴, and Adam W Anderson⁵

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Psychological Sciences, Vanderbilt University, ⁴Electrical Engineering, Vanderbilt University, ⁵Biomedical Engineering, Vanderbilt University

DTI has been used to noninvasively resolve major thalamic nuclei using an unsupervised clustering algorithm. However, rigorous validation of the method has not been studied. Here, we evaluated the method by comparing the parcellation results with histology in the same non-human primate. We found that some nuclei were clustered with larger differences from histology. That probably was because the diffusion properties of these nuclei were not coherent. In addition, the pipeline constructed in this study is also a framework to validate other approaches for thalamic nuclei parcellation.

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