Abstract #0490

Coupling of the glutamate-glutamine cycle rate with both glial and neuronal oxidative metabolism in the visual cortex of the Tupaia belangeri

Sarah Sonnay¹, Jordan Poirot², Nathalie Just³, Anne-Catherine Clerc¹, Rolf Gruetter^1,4,5, Gregor Rainer², and João M.N. Duarte¹

¹Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fedérale de Lausanne (EPFL), Lausanne, Switzerland, ²Department of Medicine, Visual Cognition Laboratory, University of Fribourg, Fribourg, Switzerland, ³University Hospital Münster, Münster, Germany, ⁴Department of Radiology, University de Lausanne, Lausanne, Switzerland, ⁵Department of Radiology, University de Geneva, Geneva, Switzerland

Cerebral function relies on cooperative interaction between neuronal and glial cells. While neuronal oxidative metabolism has been shown to be coupled to the glutamate-glutamine cycle that represents glutamatergic neurotransmission, it remains unclear whether similar coupling occurs for glial oxidative metabolism. We investigated cortical metabolism in vivo using ¹³C magnetic resonance spectroscopy (MRS) along with infusion of [1,6-¹³C]glucose during continuous stimulation of the tree shrew visual cortex (V1). Data indicate that both neuronal and glial oxidative metabolism scale with the glutamate-glutamine cycle.

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