Abstract #0365

Monitoring Resolution of Fatty Liver Disease with MRI following Bariatric Surgery: A Prospective, Multi-center Study

B. Dustin Pooler¹, Curtis Wiens¹, Alan McMillan¹, Nathan Artz², Alexandra Schlein³, Yesenia Covarrubias³, Jonathan Hooker³, Jeffrey Schwimmer³, Luke Funk¹, Guilherme Campos⁴, Jacob Greenberg¹, Garth Jacobsen³, Santiago Horgan³, Claude B. Sirlin³, and Scott B. Reeder¹

¹University of Wisconsin, Madison, WI, United States, ²St. Jude Children's Research Hospital, Memphis, TN, ³University of California-San Diego, San Diego, CA, ⁴Viginia Commonwealth University, Richmond, VA

The temporal resolution of fatty liver disease following bariatric surgery is poorly understood. We used a validated chemical shift encoded MRI (CSE-MRI) method to measure liver proton density fat fraction (PDFF) as a biomarker of liver fat. We followed a cohort of 50 obese adults undergoing bariatric surgery with pre-operative very low calorie diet (VLCD) and conclude that average liver PDFF normalizes to <5% by 6 months following bariatric surgery. Normalization of liver fat is seen in 79% of patients who lower body mass index (BMI) by ≥10 mg/k2 and 83% of patients who lose ≥30 kg.

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