Abstract #0332

Utilizing Quantitative Measurements of Carotid Intraplaque Hemorrhage can Improve on Presence Alone in Classifying Patients with and without Acute Cerebral Infarcts

Li Dong¹, Zhaoqi Zhang¹, Wei Yu¹, Sheng Wang², Qiang Shen¹, and Chun Yuan³

¹Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China, ²Department of Vascular disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China, ³Department of Radiology, University of Washington, Seattle, WA, United States

Histological studies have shown that intraplaque hemorrhage (IPH) size might be important in assessing disease severity. We hypotheses that the quantitative measurements of IPH by MRI provide additional value towards classify acute cerebral infarcts (ACI) in the carotid territory by brain MRI. We found that the subjects with ACI had larger max % IPH measurements (AUC=84.7%, p=0.015) and IPH closer to the lumen (AUC=85.4%, p=0.012). Further, using the size and distance measurements simultaneously improved the AUC to 96.9%. Beyond the presence of IPH, quantitative measurements of IPH may improve the predictive value of carotid plaque imaging for future stroke.

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