Abstract #0331

Identification of potential biomarkers for Parkinson’s disease by 1H NMR spectroscopy

Senthil Kumaran¹, Sadhana Kumari¹, Vinay Goyal², SN Dwivedi³, Achal Srivastava², and Naranamangalam R Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, ³Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

We studied the metabolic profile of urine samples of patients with Parkinson’s disease (PD) and healthy controls (HC) using 700 MHz NMR spectrometer (Varian, M/s Agilent Technologies, USA). The data were processed using Vnmrj (version:2.3A) and binning data estimated using MestReNova software (version :10.0,Mestrelab Research, Spain). PLS-DA multivariate analysis was carried out using MetaboAnalyst (ver.3.0), a web-based metabolomics data processing tool to evaluate significance of metabolites in PD with respect to HC. We observed elevated levels of lactate, tryptophan, glycine and reduced levels of citrate, leucine, isoleucine (t-test, p<0.05), suggestive of several metabolic abnormalities, as mitochondrial dysfunction and reduced bioenergetics efficiency in PD patients.

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