Abstract #0090

Dynamic PCr and pH imaging of the human lower leg muscle during exercise at 3T

Oleksandr Khegai¹, Guillaume Madelin^1,2, Ryan Brown^1,2, and Prodromos Parasoglou^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States

Dynamic phosphorous MRSI is an established non-invasive method for studying muscle metabolism. It allows quantification of the post-exercise phosphocreatine resynthesis rate, which provides insights into various physiological and pathological conditions. Due to low SNR, ³¹P imaging experiments are typically limited by long acquisition times relative to the metabolic recovery. We developed an imaging method to measure localized phosphocreatine resynthesis and pH changes in muscles of the lower leg following exercise at 3T with a high temporal resolution of 6 s required for an accurate estimation of quantitative phosphocreatine recovery rates.

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