Abstract #4406
Diffusion MRI Connectometry Findings and Symptom Reporting Following Traumatic Brain Injury
Ping-Hong Yeh 1 , Fang-Cheng Yeh 2 , John Ollinger 3 , Elyssa B. Sham 3 , Binquan Wang 1 , David Joy 1 , Justin Senseney 3 , Terrence R. Oakes 3 , and Gerard Riedy 3
1
Henry Jackson Foundation for the Advancement
of Military Medicine, Bethesda, Maryland, United States,
2
Department
of Psychology & Center for the Neural Basis of
Cognition, Carnegie Mellon University, Pittsburg,
Pennsylvania, United States,
3
National
Intrepid Center of Excellence, Bethesda, Maryland,
United States
Relating clinical symptoms to brain structural changes
is critical in understanding the sequalae following
brain injury. Due to the essence of axonal loss in TBI,
conventional tractography paradigm, requiring accurate
tracks/connectome reconstruction in order to compare the
group/individual difference, may miss lesions over the
paths failed to reconstruct tracts. Using q space
diffeomorphic reconstruction to identify affected
pathways, diffusion MRI connectometry finds local
difference in diffusion distribution,avoids any
inaccuracy in fiber tracking. We applied this approach
to relate self-reporting symptoms in military TBI
patients to the affected white matter tracts.
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