Abstract #4372
Tracking The Individual Lesion Myelination Status In Multiple Sclerosis
Hagen H Kitzler 1 , Caroline Koehler 1 , Hannes Wahl 1 , Tjalf Ziemssen 2 , and Sean C Deoni 3
1
Neuroradiology, Technische Universitaet
Dresden, Dresden, SN, Germany,
2
Neurology,
Technische Universitaet Dresden, Dresden, SN, Germany,
3
Engineering,
Brown University, Providence, RI, United States
In Multiple Sclerosis, an ongoing debate exists on
whether the disease is associated with remarkable
differences of underlying pathology and variable
subsequent degree of myelin loss within focal
demyelinating white matter lesions in early disease
states. A rapid, reliable whole-brain myelin imaging
analysis method would allow the direct testing of this
hypothesis. In fact, the in vivo observation of lesional
myelination changes would provide a direct tool to
detect response to new individualized therapeutic
approaches enhancing the intrinsic repair termed
remyelination. We present a method to retrieve the
individual myelination status of demyelinating lesions
and their change over time from mcDESPOT data.
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