Abstract #4371
Improve Myelin Imaging Biomarkers Specificity by Modeling Extra-cellular Tissue Water
Yong Wang 1,2 , Peng Sun 1 , Qing Wang 1 , Kathryn Trinkaus 3 , Robert T. Naismith 4 , Robert E. Schmidt 4 , Anne H. Cross 2,4 , and Sheng-Kwei Song 1,5
1
Radiology, Washington University in St.
Louis, Saint Louis, MO, United States,
2
Hope
Center for neurological Disorders, Washington University
in St. Louis, Saint Louis, MO, United States,
3
Biostatistics,
Washington University in St. Louis, Saint Louis, MO,
United States,
4
Neurology,
Washington University in St. Louis, Saint Louis, MO,
United States,
5
Hope
Center for neurological Disorders, Washington University
in St. Louis, Saint Louis, m, United States
Diffusion tenor imaging (DTI) radial diffusivity (RD)
and magnetization transfer ratio (MTR) are known
sensitive to myelin integrity. However, the specificity
of DTI and MTR are suboptimal. In this study, both
histological myelin quantification and diffusion MRI
were conducted on MS spinal cord specimens to assess the
effect of extra-cellular tissue water on the specificity
of DTI RD. Preliminary findings suggested that
extra-cellular tissue water confounded myelin imaging
specificity of DTI RD. Findings were also extended to
diffusion MRI and MTR of living patients. By
differentiating extra-cellular tissue water, myelin
imaging specificity can be significantly improved by
diffusion basis spectrum imaging (DBSI).
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