Abstract #4332
Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone-induced demyelination and spontaneous remyelination
Caroline Guglielmetti 1 , Jelle Veraart 2 , Ella Roelant 3 , Zhenhua Mai 4 , Jasmijn Daans 5 , Johan Van Audekerke 4 , Jelle Praet 4 , Peter Ponsaerts 5 , jan Sijbers 2 , Annemie Van der Linden 4 , and Marleen Verhoye 4
1
Bio Imaging Lab, University of Antwerp,
WILRIJK, ANTWERPEN, Belgium,
2
IBBT
Vision LaboratoryDepartment of Physics, University of
Antwerp, ANTWERPEN, Belgium,
3
StatUa
Center for Statistics, University of Antwerp, ANTWERPEN,
Belgium,
4
Bio
Imaging Lab, University of Antwerp, ANTWERPEN, Belgium,
5
Experimental
Cell Transplantation Group, Laboratory of Experimental
Hematology, Vaccine and Infect, ANTWERPEN, Belgium
Sensitivity of diffusion kurtosis imaging (DKI) to
detect microstructural alterations has been demonstrated
in patients suffering from several neurological
disorders. Despite advances in neuroimaging techniques,
the majority of cortical alterations present in multiple
sclerosis patients still fail to be detected. In this
work, we used the well characterized cuprizone mouse
model for brain demyelination and evaluated the
sensitivity of in vivo DKI measurements for the
non-invasive detection of cortical grey matter and white
matter alterations. We showed that DKI can probe
cortical demyelination and allow the detection of white
matter inflammation and demyelination following
cuprizone administration.
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