Abstract #4331
Vascular Expansion and Blood-Brain-Barrier Permeability: A Comparative Volumetric Study in Acute Japanese Macaque Encephalomyelitis
Ian Tagge 1,2 , Steven Kohama 3 , Jim Pollaro 1 , Lawrence Sherman 3 , Dennis Bourdette 4 , Randy Woltjer 4 , Scott Wong 3 , and William Rooney 1,2
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Biomedical
Engineering, Oregon Health & Science University,
Portland, OR, United States,
3
Oregon
National Primate Research Center, Oregon Health &
Science University, OR, United States,
4
Neurology,
Oregon Health & Science University, Portland, Oregon,
United States
Inflammation, blood brain barrier (BBB) compromise, and
vascular recruitment are common in neurodegenerative
diseases. Gadolinium based contrast agents (GBCA) reveal
BBB permeability. Blood pool contrast agents probe
cerebral blood volume in-vivo. Japanese Macaque
Encephalomyelitis (JME) is a spontaneous demyelinating
disease similar to human multiple sclerosis. We use
bolus injection of ferumoxytol (FeO) to investigate
vascular expansion in acute JME. FeO accumulation
indicates macrophage activity in and around acute
lesions in JME. GBCA and FeO enhancements are
colocalized, with the FeO volume generally exceeding
that of GBCA. These findings suggest that vascular
expansion extends well beyond the area of BBB
compromise.
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