Abstract #4324
Comparisons of QSM Data obtained from a single echo and multiple echoes in patients with cognitive normal, mild cognitive impairment, and Alzheimer s Disease
Hyug-Gi Kim 1 , Dan-Bi Kim 2 , Jang-Hoon Oh 1 , Hak Young Rhee 3 , Chang-Woo Ryu 2 , Soon Chan Park 2 , Dal-Mo Yang 2 , Yi Wang 1,4 , Tian Liu 4 , and Geon-Ho Jahng 2
1
Biomedical Engineering, Kyung Hee
University, YoungIn, Gyeonggi-do, Korea,
2
Radiology,
Kyung Hee University Hospital-Gangdong, Seoul, Korea,
3
Neurology,
Kyung Hee University Hospital-Gangdong, Seoul, Korea,
4
Biomedical
Engineering and Radiology, Cornell University, New York,
New York, United States
To estimate the quantitative susceptibility effect on a
number of echoes of gradient-echo sequences, two
sequences were run in subjects with cognitive normal
(CN), mild cognitive impairment (MCI) and Alzheimers
diseases (AD). Quantitative susceptibility mapping (QSM)
was reconstructed with the single-echo (seQSM) and with
multiple-echo (meQSM) data. QSM maps were compared among
three groups. We found higher sensitivity of meQSM data
than seQSM data. The meQSM technique has been proposed
to accurately estimate the amounts of irons compared
with seQSM technique. In addition, QSM was useful to
investigate susceptibility effects in AD brain with the
voxel-based analyses.
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