Abstract #4323
Diffusion kurtosis imaging reveals widespread white matter abnormalities in Alzheimer' s disease
Weiwei Wang 1 , Rui Hu 1 , Ziheng Zhang 2 , Qingwei Song 1 , Ailian Liu 1 , and Yanwei Miao 1
1
Radiology Department, the First Affiliated
Hospital of Dalian Medical University, Dalian, Liaoning,
China,
2
GE
Healthcare China, Beijing, China
Alzheimer's disease (AD) is the most common CNS
degenerative disease in aged people and causes senile
dementia1. Diffusion kurtosis imaging (DKI) is a method
that can obtain the non-Gaussian diffusion of water.
This work was to evaluate the application of DKI on
white matter microstructure damage examination in AD,
and it was found DKI can quantitatively evaluate the
white matter changes in AD patients and the Dr values in
the temporal WM can be as the best individual biomarkers
of differentiation AD to controls. In addition, the
changes of DKI parameters indicated the axonal loss and
myelin damage of AD
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