Abstract #4303
Multimodal MRI of a novel transgenic model of Parkinsons Disease (MitoPark mice)
Linlin Cong 1 , Eric R. Muir 1 , Yusheng Qian 2 , Cang Chen 2 , Senlin Li 2 , and Timothy Q. Duong 1
1
Research Imaging Institute, University of
Texas Healthy Science Center at San Antonio, san
antonio, Texas, United States,
2
Departments
of Medicine and Pharmacology, University of Texas
Healthy Science Center at San Antonio, san antonio,
Texas, United States
Parkinsons disease (PD), the second most prevalent
neurodegenerative disorder, is characterized by a number
of motor symptoms. MitoPark transgenic mouse is a
relatively new model of PD that exhibits several
critical clinical features of PD, including progressive
neurodegeneration and death of dopamine neurons,
followed by motor dysfunction. This study investigated
CBF, ADC and T2* in the caudate putamen and substantia
nigra of MitoPark mice. MitoPark mice showed trends of
reduced ADC and CBF, and significantly reduced T2* value
compared to controls. These results were corroborated
with behavioral deficits in loco-motor activity and
histological loss of dopamine neurons.
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