Abstract #4302
Region-specific disturbed iron distribution in early idiopathic Parkinsons disease measured by quantitative susceptibility mapping
Naying He 1 , Fuhua Yan 2 , Huawei Ling 2 , Yong Zhang 3 , and Zhongping Zhang 4
1
Ruijin Hospital,Shanghai Jiao Tong
University School of Medicine, Shanghai, Shanghai,
China,
2
Ruijin
Hospital,Shanghai Jiao Tong University School of
Medicine, Shanghai, China,
3
MR
Research, GE Healthcare, China, Shanghai, China,
4
MR
Research, GE Healthcare, China, Guangzhou, China
A reliable in vivo quantitative evaluation of iron
deposition is important, especially in early PD. Several
technical problems prevent the conventional GRE
approaches from quantitatively detect local
susceptibility changes which are assumed to reflect iron
depositions in brain regions. In this work, we utilized
a novel post-processing method, quantitative
susceptibility mapping (QSM) to investigate the iron
deposition changes in early PD, and explore their
relationships with clinical futures. The results
indicate that QSM is useful for quantitatively detection
of iron alteration in brain, which might be an early
event in the progression of PD.
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