Abstract #4295
An Arterial Spin Labelling Study Revealing Altered Neurovascular Status in Idiopathic Parkinson's Disease; Comparisons with Cerebrovascular Disease
Sarah Al-Bachari 1 , Hedley Emsley 2 , Rishma Vidyasagar 1,3 , and Laura Parkes 4
1
Imaging, University of Manchester,
Manchester, United Kingdom,
2
Neurology,
Royal Preston Hospital, Preston, Lancashire, United
Kingdom,
3
Department
of Anatomy and Neurosciences, University of
Melbourne,Victoria, Victoria, 3010, Australia,
4
Imaging,
Manchester University, Manchester, United Kingdom
Idiopathic Parkinsons disease (IPD) is the second most
common neurodegenerative disorder; vascular mechanisms
are rapidly emerging as key players in the
neurodegenerative process in preclinical studies, yet
clinical studies remain equivocal. To investigate the
neurovascular status in IPD we used arterial spin
labelling (ASL) MRI techniques measuring cerebral blood
flow (CBF) and arterial arrival time (AAT), comparing
findings to patients with known cerebrovascular disease
(CVD) and healthy controls. Results revealed a diffuse
widespread increase in AAT in the IPD group compared to
controls, which was similar to, but more pronounced than
the prolongation of AAT seen in CVD, providing evidence
of an alteration in neurovascular status.
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