Abstract #4294
MRI patterns of atrophy associated with Parkinsons subtypes
Yue Xing 1 , Stefan Schwarz 1 , Nin Bajaj 2 , Penny Gowland 3 , and Dorothee Auer 1
1
Sir Peter Mansfield Imaging Centre, School
of Medicine, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
2
Division
of Neurology, Nottingham University Hospitals NHS Trust,
Nottingham, Nottinghamshire, United Kingdom,
3
Sir
Peter Mansfield Imaging Centre, School of Physics and
Astronomy, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom
To assess whether gray matter (GM) atrophy between 2
Parkinson disease (PD) subtypes: the tremor dominant
(TD) subtype and the postural instability gait
difficulty (PIGD), we used multivariate pattern
classification analysis (MVPA) on cortical thickness in
people with Parkinsons. Our result show MVPA is
sensitive to discriminate the patterns of GM loss of
these two subtypes, which suggest GM atrophy may provide
useful information for classification different motor
subgroup of PD.
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