Abstract #4242
Dystrophic Skeletal Muscle 1 H 2 O T 2 Analyzed for Multiple Components
Sean C Forbes 1 , William T Triplett 1 , Rebecca Willcocks 1 , Abhinandan Batra 1 , Ravneet Vohra 1 , James Pollaro 2 , Dah-Jyuu Wang 3 , Richard Finkel 4 , Barry J Byrne 5 , Barry S Russman 6 , Erika Finanger 6 , Michael Daniels 7 , William Rooney 2 , Glenn A Walter 1 , H Lee Sweeney 8 , and Krista Vandenborne 1
1
University of Florida, Gainesvillle,
Florida, United States,
2
Oregon
Health & Science University, Oregon, United States,
3
The
Children's Hospital of Philadelphia, Pennsylvania,
United States,
4
Nemours
Children's Hospital, Florida, United States,
5
University
of Florida, Gainesville, Florida, United States,
6
Shriners
Hospital, Oregon, United States,
7
University
of Texas at Austin, Texas, United States,
8
University
of Pennsylvania, Pennsylvania, United States
This study evaluated
1
H
2
O
T
2
of
skeletal muscle in boys with Duchenne muscular dystrophy
(DMD) and unaffected controls, and in dystrophic mice
before and after downhill running. Data were acquired
using single voxel
1
H-MRS
and analyzed for multiple components using non-negative
least squares analyses (NNLS). NNLS revealed differences
between dystrophic muscle and controls, including DMD
having a more predominant long component. The long
component was affected by corticosteroid treatment and
downhill running in dystrophic muscle and was consistent
with muscle damage/inflammation contributing to this
component. Overall, NNLS analyses may provide valuable
insight when interpreting
1
H
2
O
T
2
changes
in dystrophic muscle.
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